Zhang, F, Mohamed, MO, Ensor, J, Peat, G and Mamas, MA (2020) Temporal Trends in Comorbidity Burden and Impact on Prognosis in Patients With Acute Coronary Syndrome Using the Elixhauser Comorbidity Index Score. American Journal of Cardiology, 25 (11). pp. 1603-1611. ISSN 1879-1913

[thumbnail of AMI Elixhauser paper resubmission AJC.docx] Text
AMI Elixhauser paper resubmission AJC.docx - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (81kB)


Despite current evidence, little is known about the impact of comorbidity burden on invasive management strategies and clinical outcomes in the context of acute coronary syndrome (ACS). All ACS hospitalizations between 2004 and 2014 from the National Inpatient Sample were included, stratified by Elixhauser Comorbidity Score (ECS) and number of Elixhauser Comorbidities (NEC) to compare the receipt of invasive management and clinical outcomes between different ECS and NEC classes to the lowest class of either measure. A total of 6,613,623 records with ACS were included in the analysis. Overall comorbidity burden increased over the 11-year period, with higher comorbidity classes (ECS ≥ 14 and NEC ≥ 5) increasing from 2.1% to 4.6% and 4% to 16%, respectively. Higher ECS and NEC classes negatively correlated with the rates of utilization of coronary angiography (CA) and percutaneous coronary intervention (PCI) (ECS ≥14 vs <0: CA: 38.2% vs 69.3%, PCI: 18.6% vs 45.3%; NEC ≥5 vs 0: CA: 49.3% vs 73.4%, PCI: 24.4% vs 57.4%). Overall, higher ECS and NEC classes were independently associated with significantly increased odds of all complications, including major acute cardiovascular and cerebrovascular events, mortality, stroke and bleeding. In conclusion, among patients hospitalized for ACS, a higher comorbidity number or severity is associated with lower rates of receipt of CA and PCI, but not coronary artery bypass grafting, and worse clinical outcomes. Comorbidity burden assessment using ECS can help stratify patient groups at greatest risk of adverse outcomes in which invasive management is currently underutilized.

Item Type: Article
Additional Information: The final accepted manuscript and all relevant information can be found at; https://www.sciencedirect.com/science/article/pii/S000291492030223X?via%3Dihub
Uncontrolled Keywords: Comorbidity Burden; Elixhauser Comorbidity Index Score; Coronary Syndrome
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 04 May 2020 11:35
Last Modified: 17 Mar 2021 01:30
URI: https://eprints.keele.ac.uk/id/eprint/7930

Actions (login required)

View Item
View Item