Kwok, CS, Rashid, M, Fraser, D, Nolan, J and Mamas, M (2015) Intra-arterial vasodilators to prevent radial artery spasm: a systematic review and pooled analysis of clinical studies. Cardiovascular Revascularization Medicine, 16 (8). pp. 484-490. ISSN 1553-8389

[thumbnail of M Mamas - Intra-arterial vasodilators to prevent radial artery spasm - a systematic review and pooled analysis of clinical studies.pdf]
M Mamas - Intra-arterial vasodilators to prevent radial artery spasm - a systematic review and pooled analysis of clinical studies.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (352kB) | Preview


The aim of this study is to review the available literature on the efficacy and safety of agents used for prevention of RAS.

Different vasodilator agents have been used to prevent radial artery spasm (RAS) in patients undergoing transradial cardiac catheterization.

We included studies that evaluated any intra-arterial drug administered in the setting cardiac catheterization that was undertaken through the transradial access site (TRA). We also compared studies for secondary outcomes of major bleeding, procedure time, and procedure failure rate in setting of RAS prevention, patent hemostasis and radial artery occlusion.

22 clinical studies met the inclusion criteria. For placebo, RAS rate was 12% (4 studies, 638 participants), which was similar to 2.5 mg of verapamil 12% (3 studies, 768 participants) but greater than 5 mg of verapamil (4%, 2 studies, 497 participants). For nicorandil, there was a much higher RAS rate compared to placebo (16%, 3 studies, 447 participants). The lowest rates of RAS was found for nitroglycerin at both 100 μg (4%) and 200 μg (2%) doses, isosorbide mononitrate (4%) and nicardipine (3%). We found no information regarding the procedure failure rates, patent hemostasis, and radial artery occlusion in these studies.

In this largest and up-to-date review on intra-arterial vasodilators use to reduce RAS, we have found that the verapamil at a dose of 5 mg or verapamil in combination with nitroglycerine are the best combinations to reduce RAS.

Item Type: Article
Uncontrolled Keywords: Vasodilator, Radial artery catheterization, Radial artery spasm
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 17 Aug 2015 08:13
Last Modified: 24 Apr 2019 10:50

Actions (login required)

View Item
View Item