Wing-Yee Kwok
Comparison of clinical burden between patients with erosive hand osteoarthritis and inflammatory arthritis in symptomatic community-dwelling adults: the Keele clinical assessment studies.
Kwok, Wing-Yee; Kloppenburg, Margreet; Marshall, Michelle; Nicholls, Elaine; Rosendaal, Frits R.; Van Der Windt, Danielle A.; Peat, George
Authors
Margreet Kloppenburg
Dr Michelle Marshall m.marshall@keele.ac.uk
Elaine Nicholls e.nicholls@keele.ac.uk
Frits R. Rosendaal
Danielle Van Der Windt d.van.der.windt@keele.ac.uk
George Peat
Abstract
OBJECTIVE: To investigate in the general population the clinical impact of erosive OA in interphalangeal joints (IPJs) compared with symptomatic radiographic hand OA and inflammatory arthritis. METHODS: Standardized assessments with hand radiographs were performed in participants of two population-based cohorts in North Staffordshire with hand symptoms lasting =1 day in the past month. Erosive OA was defined as the presence of an eroded or remodelled phase in =1 IPJ using the Verbruggen-Veys method. Radiographic hand OA was defined as the presence of =1 IPJ/first carpometacarpal joint with a Kellgren-Lawrence score of =2. Diagnoses of inflammatory arthritis were based on medical records. Hand pain and disability were assessed with the Australian/Canadian Hand Osteoarthritis Index (AUSCAN). Linear regression analyses were used to compare clinical determinants between groups and calculate mean differences with 95% CIs, adjusted for age and sex. RESULTS: Of 1076 participants with hand symptoms [60% women, mean age 64.8 years (s.d. 8.3 years)]; 80 persons (7.4%) had erosive OA. The population prevalence of erosive OA in =1 IPJ was 2.4% (95% CI 1.8, 3.0). Persons with erosive OA reported more pain and disability than persons with symptomatic radiographic hand OA [adjusted mean difference 1.3 (95% CI 0.3, 2.3) and 2.3 (95% CI 0.4, 4.2), respectively]. Individuals with inflammatory arthritis (n = 44) reported more pain and disability than those with erosive OA [adjusted mean difference 1.7 (95% CI 0.05, 3.4) and 6.3 (95% CI 2.8, 9.9), respectively]. CONCLUSION: While erosive OA has a greater impact than symptomatic radiographic hand OA in the general population, it is not as severe in terms of hand pain and disability as inflammatory RA.
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 17, 2013 |
Online Publication Date | Sep 17, 2013 |
Publication Date | 2013-12 |
Journal | Rheumatology (Oxford) |
Print ISSN | 1462-0324 |
Publisher | Oxford University Press |
Peer Reviewed | Peer Reviewed |
Volume | 52 |
Issue | 12 |
Pages | 2260 - 2267 |
DOI | https://doi.org/10.1093/rheumatology/ket267 |
Keywords | erosions, hand osteoarthritis, inflammatory arthritis, pain, function |
Publisher URL | https://academic.oup.com/rheumatology/article/52/12/2260/1801355 |
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