Edelstyn, NM and Martini, A (2020) Incentive-driven decision-making networks in de novo and drug-treated Parkinson’s disease patients with impulsive-compulsive behaviors: A systematic review of neuroimaging studies. Parkinsonism and Related Disorders, 78. pp. 165-177. ISSN 1873-5126

[thumbnail of PARKRELDIS-D-20-00596R1 (2)-pagine-eliminate.pdf]
PARKRELDIS-D-20-00596R1 (2)-pagine-eliminate.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (975kB) | Preview


Background: In Parkinson’s disease (PD), impulsive-compulsive behaviors (ICBs) may develop as side-effect of dopaminergic medications. Abnormal incentive-driven decision-making, which is supported by the cognitive control and motivation interaction, may represent an ICBs signature. This systematic review explored whether structural and/or functional brain differences between PD patients with vs without ICBs encompass incentive-driven decision-making networks. Methods: Structural and functional neuroimaging studies comparing PD patients with and without ICBs, either de novo or medicated, were included. Results: Thirty articles were identified. No consistent evidence of structural alteration both in de novo and medicated PD patients were found. Differences in connectivity within the default mode, the salience and the central executive networks predate ICBs development and remain stable once ICBs are fully developed. Medicated PD patients with ICBs show increased metabolism and cerebral blood flow in orbitofrontal and cingulate cortices, ventral striatum, amygdala, insula, temporal and supramarginal gyri. Abnormal ventral striatum connectivity with anterior cingulate cortex and limbic structures was reported in PD patients with ICBs. Discussion: Functional brain signatures of ICBs in PD encompass areas involved in cognitive control and motivational encoding networks of the incentive-driven decision-making. Functional alterations predating ICBs may be related to abnormal synaptic plasticity in these networks.

Item Type: Article
Additional Information: The final accepted version of this article and all relevant information related to this paper can be found at; https://www.sciencedirect.com/science/article/pii/S135380202030657X
Uncontrolled Keywords: Parkinson’s disease; impulsive-compulsive behavior; impulse control disorder; neuroimaging; motivation; de novo; dopaminergic treatment; cognitive control; incentive-driven decision-making; MRI.
Subjects: B Philosophy. Psychology. Religion > BF Psychology
H Social Sciences > H Social Sciences (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC435 Psychiatry
Divisions: Faculty of Natural Sciences > School of Psychology
Depositing User: Symplectic
Date Deposited: 28 Jul 2020 14:56
Last Modified: 28 Jul 2021 01:30
URI: https://eprints.keele.ac.uk/id/eprint/8435

Actions (login required)

View Item
View Item