Sebastian Cosgrove s.cosgrove@keele.ac.uk
Is it time for biocatalysis in fragment-based drug discovery?
Cosgrove
Authors
Abstract
The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.
Acceptance Date | Oct 7, 2020 |
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Publication Date | Nov 7, 2020 |
Publicly Available Date | Mar 28, 2024 |
Journal | Chemical Science |
Print ISSN | 2041-6520 |
Publisher | Royal Society of Chemistry |
Pages | 11104 - 11112 |
DOI | https://doi.org/10.1039/D0SC04103C |
Keywords | fragment-based drug discovery, biocatalysis, chemistry |
Publisher URL | https://pubs.rsc.org/en/content/articlelanding/2020/SC/D0SC04103C#!divAbstract |
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/
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