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Ramsden, JI, Cosgrove, SC and Turner, NJ (2020) Is it time for biocatalysis in fragment-based drug discovery? Chemical Science, 11 (41). 11104 - 11112. ISSN 2041-6520
RSC final version.pdf - Accepted Version
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Abstract
The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.
Item Type: | Article |
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Additional Information: | The final version of this article and all relevant information related to it can be found online at; https://pubs.rsc.org/en/content/articlelanding/2020/SC/D0SC04103C#!divAbstract |
Uncontrolled Keywords: | fragment-based drug discovery, biocatalysis, chemistry |
Subjects: | R Medicine > R Medicine (General) > R735 Medical education. Medical schools. Research R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine R Medicine > RZ Other systems of medicine |
Divisions: | Faculty of Natural Sciences > School of Chemical and Physical Sciences |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 18 Nov 2020 12:38 |
Last Modified: | 21 Nov 2020 15:25 |
URI: | https://eprints.keele.ac.uk/id/eprint/8911 |