González-González, AI, Dinh, TS, Meid, AD, Blom, JW, van den Akker, M, Elders, PJM, Thiem, U, Kuellenberg de Gaudry, D, Snell, KIE, Perera, R, Swart, KMA, Rudolf, H, Bosch-Lenders, D, Trampisch, H-J, Meerpohl, JJ, Flaig, B, Kom, G, Gerlach, FM, Hafaeli, WE, Glasziou, PP and Muth, C (2021) Predicting negative health outcomes in older general practice patients with chronic illness: Rationale and development of the PROPERmed harmonized individual participant data database. Mechanisms of Ageing and Development, 194 (111436). ISSN 0047-6374

[thumbnail of PROPERmed rationale final ACCEPTED.pdf]
PROPERmed rationale final ACCEPTED.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (464kB) | Preview


The prevalence of multimorbidity and polypharmacy increases significantly with age and are associated with negative health consequences. However, most current interventions to optimize medication have failed to show significant effects on patient-relevant outcomes. This may be due to ineffectiveness of interventions themselves but may also reflect other factors: insufficient sample sizes, heterogeneity of population. To address this issue, the international PROPERmed collaboration was set up to obtain/synthesize individual participant data (IPD) from five cluster-randomized trials. The trials took place in Germany and The Netherlands and aimed to optimize medication in older general practice patients with chronic illness. PROPERmed is the first database of IPD to be drawn from multiple trials in this patient population and setting. It offers the opportunity to derive prognostic models with increased statistical power for prediction of patient-relevant outcomes resulting from the interplay of multimorbidity and polypharmacy. This may help patients from this heterogeneous group to be stratified according to risk and enable clinicians to identify patients that are likely to benefit most from resource/time-intensive interventions. The aim of this manuscript is to describe the rationale behind PROPERmed collaboration, characteristics of the included studies/participants, development of the harmonized IPD database and challenges faced during this process.

Item Type: Article
Additional Information: The final version of this accepted manuscript and all relevant information, including copyrights, can be found online at; https://www.sciencedirect.com/science/article/pii/S0047637421000087?via%3Dihub
Uncontrolled Keywords: Elderly; Hospitalization; Meta-analysis; Multimorbidity; Polypharmacy; Prognosis; Quality of life
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 26 Feb 2021 09:52
Last Modified: 15 Jan 2022 01:30
URI: https://eprints.keele.ac.uk/id/eprint/9184

Actions (login required)

View Item
View Item