Crocker, TF, Clegg, A, Riley, RD, Lam, N, Bajpai, R, Jordão, M, Patetsini, E, Ramiz, R, Ensor, J, Forster, A and Gladman, JRF (2021) Community-based complex interventions to sustain independence in older people, stratified by frailty: a protocol for a systematic review and network meta-analysis. BMJ Open, 11 (2). e045637 - ?. ISSN 2044-6055

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INTRODUCTION: Maintaining independence is a primary goal of community health and care services for older people, but there is currently insufficient guidance about which services to implement. Therefore, we aim to synthesise evidence on the effectiveness of community-based complex interventions to sustain independence for older people, including the effect of frailty, and group interventions to identify the best configurations. METHODS AND ANALYSIS: Systematic review and network meta-analysis (NMA). We will include randomised controlled trials (RCTs) and cluster RCTs of community-based complex interventions to sustain independence for older people living at home (mean age ≥65 years), compared with usual care or another complex intervention. We will search MEDLINE (1946 to September 2020), Embase (1947 to September 2020), CINAHL (1981 to September 2020), PsycINFO (1806 to September 2020), CENTRAL and clinical trial registries from inception to September 2020, without date/language restrictions, and scan included papers' reference lists. Main outcomes were: living at home, activities of daily living (basic/instrumental), home-care services usage, hospitalisation, care home admission, costs and cost effectiveness. Additional outcomes were: health status, depression, loneliness, falls and mortality. Interventions will be coded, summarised and grouped. An NMA using a multivariate random-effects model for each outcome separately will determine the relative effects of different complex interventions. For each outcome, we will produce summary effect estimates for each pair of treatments in the network, with 95% CI, ranking plots and measures, and the borrowing of strength statistic. Inconsistency will be examined using a 'design-by-treatment interaction' model. We will assess risk of bias (Cochrane tool V.2) and certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation for NMA approach. ETHICS AND DISSEMINATION: This research will use aggregated, anonymised, published data. Findings will be reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance. They will be disseminated to policy-makers, commissioners and providers, and via conferences and scientific journals. PROSPERO REGISTRATION NUMBER: CRD42019162195.

Item Type: Article
Additional Information: This is the final published version (version of record). It was first published online via BMJ at - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: clinical trials, geriatric medicine, occupational & industrial medicine, preventive medicine, Primary care, rehabilitation medicinE
Subjects: R Medicine > RC Internal medicine > RC952 Geriatrics
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Depositing User: Symplectic
Date Deposited: 26 Feb 2021 17:12
Last Modified: 11 Jun 2021 14:52

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