Frempong, SN, Goranitis, I and Oppong, R (2015) Economic evaluation alongside factorial trials: a systematic review of empirical studies. Expert Review of Pharmacoeconomics and Outcomes Research, 15 (5). pp. 801-811. ISSN 1744-8379

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Although economic evaluations have been performed alongside factorial trials, there seems to be limited guidance/consensus on appropriate methods of analysis. Following Centre for Review and Dissemination guidance, a systematic review of published literature for all years was performed to explore how economic evaluation alongside factorial trials have been conducted and only full economic evaluations conducted alongside factorial trials were included. A total of 16 relevant studies were identified, and an assessment of these indicated that two methods: within-the-table and at-the-margins approaches were used for the analysis. With the exception of one study, all others did not consider interactions in costs and outcomes or give a detailed explanation of why a particular approach was adopted. The authors recommend that additional guidance is needed, and further research is required to evaluate the impact of alternative methods on policy recommendations and establish good practice methods for the economic analysis of factorial trials.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Taylor & Francis at Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: cost-benefit analysis, cost–effectiveness, cost-utility analysis, economic evaluation, factorial design, factorial trial
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 17 Sep 2015 14:40
Last Modified: 13 Jun 2018 09:47

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