Steadman, CD, Razvi, NA, Snell, KIE, Kuijer, JPA, van Rossum, AC and McCann, GP (2011) Comparison and reproducibility of standard and high temporal resolution myocardial tissue tagging in patients with severe aortic stenosis. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 13 (S1). P311 - P311. ISSN 1097-6647

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The aim of this study was to compare and assess the reproducibility of left ventricular (LV) circumferential peak systolic strain (PeakEcc) and strain rate (SR) measurements using standard and high temporal resolution myocardial tissue tagging in patients with severe aortic stenosis (AS).

Myocardial tissue tagging with cardiac magnetic resonance (CMR) can be used to quantify strain and SR, however, there are little data on the reproducibility. Diastolic SR may be of particular interest as it may be the most sensitive marker of diastolic dysfunction often occurring early in the course of disease.

Eight patients with isolated severe AS without obstructive coronary artery disease were prospectively enrolled. They underwent CMR in a 1.5T scanner (Siemens Avanto) on two separate occasions, median interval 12 days. Complementary tagged (CSPAMM) images were acquired with both a single breath-hold (SBH: temporal resolution 42ms), and a multiple brief expiration breath-hold (MBH: high temporal resolution 17ms) sequence. Mid-wall PeakEcc was measured in the LV at mid-ventricular level with HARP Version 2.7 (Diagnosoft, USA). SR was calculated from the strain data; SR=Ecc2-Ecc1/Time2-Time1. PeakEcc , peak systolic and diastolic SR were read from curves of strain and SR against time. The MBH SR curves were filtered with a moving average (MA) to reduce noise sensitivity, results from a sample width of three and five were examined. Differences between SBH and MBH were assessed using Wilcoxon signed-rank test as not all measures were normally distributed. Reproducibility assessments were carried out on all techniques.

PeakEcc was significantly higher with MBH vs. SBH, but reproducibility was slightly worse. Results are summarised in Table 1. Systolic SR was approximately equal with all techniques although MBH using MA of five led to a borderline significant reduction. Diastolic SR was higher when measured with MBH although only significant using MA of three. Systolic and diastolic SR measures were more reproducible with MBH compared with SBH, except for the diastolic SR using MA of three, which was substantially worse. Strain and SR curves for the same patient are shown in Figure 1.

Item Type: Article
Additional Information: This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Depositing User: Symplectic
Date Deposited: 03 Mar 2021 10:35
Last Modified: 03 Mar 2021 10:35

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