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Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review.

Mamas

Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review. Thumbnail


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Abstract

AIM: To identify existing comorbidity measures and summarise their association with acute coronary syndrome (ACS) outcomes. METHODS: We searched published studies from MEDLINE (OVIDSP) and EMBASE from inception to March 2021, studies of the pre-specified conference proceedings from Web of Science since May 2017, and studies included in any relevant systematic reviews. Studies that reported no comorbidity measures, no association of comorbid burden with ACS outcomes, or only used a comorbidity measure as a confounder without further information were excluded. After independent screening by three reviewers, data extraction and risk of bias assessment of each included study was undertaken. Results were narratively synthesised. RESULTS: Of 4166 potentially eligible studies identified, 12 (combined n=6,885,982 participants) were included. Most studies had a high risk of bias at quality assessment. Six different types of comorbidity measures were identified with the Charlson comorbidity index (CCI) the most widely used measure among studies. Overall, the greater the comorbid burden or the higher comorbidity scores recorded, the greater was the association with the risk of mortality. CONCLUSION: The review summarised different comorbidity measures and reported that higher comorbidity scores were associated with worse ACS outcomes. The CCI is the most widely measure of comorbid burden and shows additive value to clinical risk scores in use.

Acceptance Date May 11, 2021
Publication Date May 11, 2021
Publicly Available Date Mar 29, 2024
Journal International Journal of Clinical Practice
Print ISSN 1368-5031
Publisher Wiley
Pages e14345 - ?
DOI https://doi.org/10.1111/ijcp.14345
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/ijcp.14345