Zhang, F, Wong, C, Chiu, Y, Ensor, J, Mohamed, MO, Peat, G and Mamas, MA (2021) Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: a systematic review. International Journal of Clinical Practice. e14345 - ?. ISSN 1742-1241

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AIM: To identify existing comorbidity measures and summarise their association with acute coronary syndrome (ACS) outcomes. METHODS: We searched published studies from MEDLINE (OVIDSP) and EMBASE from inception to March 2021, studies of the pre-specified conference proceedings from Web of Science since May 2017, and studies included in any relevant systematic reviews. Studies that reported no comorbidity measures, no association of comorbid burden with ACS outcomes, or only used a comorbidity measure as a confounder without further information were excluded. After independent screening by three reviewers, data extraction and risk of bias assessment of each included study was undertaken. Results were narratively synthesised. RESULTS: Of 4166 potentially eligible studies identified, 12 (combined n=6,885,982 participants) were included. Most studies had a high risk of bias at quality assessment. Six different types of comorbidity measures were identified with the Charlson comorbidity index (CCI) the most widely used measure among studies. Overall, the greater the comorbid burden or the higher comorbidity scores recorded, the greater was the association with the risk of mortality. CONCLUSION: The review summarised different comorbidity measures and reported that higher comorbidity scores were associated with worse ACS outcomes. The CCI is the most widely measure of comorbid burden and shows additive value to clinical risk scores in use.

Item Type: Article
Additional Information: The final version of this accepted manuscript and all relevant information related to it can be found online at; https://onlinelibrary.wiley.com/doi/10.1111/ijcp.14345
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Faculty of Medicine and Health Sciences > School of Primary, Community and Social Care
Related URLs:
Depositing User: Symplectic
Date Deposited: 19 May 2021 08:32
Last Modified: 19 May 2021 08:32
URI: https://eprints.keele.ac.uk/id/eprint/9589

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