Woods, W, Evans, D, Mogas Barcons, A, Tzerakis, N, Adams, CF and Chari, DM (2021) Stem cell sprays for neurological injuries: a perspective. Emerging Topics in Life Sciences. ISSN 2397-8554

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<jats:p>Injuries to the brain and spinal cord have major clinical consequences with high costs for healthcare systems. Neural cell transplantation therapies have significant translational potential to promote regeneration post-injury with clinical trials commencing for various pathologies. However, there are challenges associated with current clinical approaches used for systemic or direct delivery of transplant cells to neural tissue in regenerative applications. These include risks associated with surgical microinjection into neural tissue (e.g. haemorrhage, cell clumping) and high cell loss due to systemic clearance or with cell passage through fine gauge needles into densely packed neural tissue. This article presents lines of evidence supporting the concept that cell spray delivery technology can offer significant translational benefits for neural transplantation therapy, versus current cell delivery methods. Potential benefits include rapid/homogenous cell delivery, release over large surface areas, minimal invasiveness, compatibility with neurosurgical procedures in acute injury, no predictable clinical complications and the capacity to combine cell therapies with drug/biomolecule delivery. Accordingly, we consider that the development of cell spray delivery technology represents a key goal to develop advanced cell therapies for regenerative neurology.</jats:p>

Item Type: Article
Additional Information: © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology All relevant information for this article, including copyrights, can be found online at; https://portlandpress.com/emergtoplifesci/article-abstract/doi/10.1042/ETLS20210113/228944/Stem-cell-sprays-for-neurological-injuries-a?redirectedFrom=fulltext
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders
Divisions: Faculty of Medicine and Health Sciences > School of Medicine
Faculty of Natural Sciences > School of Life Sciences
Depositing User: Symplectic
Date Deposited: 04 Aug 2021 11:57
Last Modified: 07 Jun 2022 01:30
URI: https://eprints.keele.ac.uk/id/eprint/9850

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