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Ponts, N, Yang, J, Chung, DW, Prudhomme, J, Girke, T, Horrocks, P and Le Roch, KG (2008) Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence. PLoS One, 3 (6). e2386 - ?. ISSN 1932-6203
Deciphering the ubiquitin-mediated pathway in apicomplexan parasites: a potential strategy to interfere with parasite virulence..pdf
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Abstract
Reversible modification of proteins through the attachment of ubiquitin or ubiquitin-like modifiers is an essential post-translational regulatory mechanism in eukaryotes. The conjugation of ubiquitin or ubiquitin-like proteins has been demonstrated to play roles in growth, adaptation and homeostasis in all eukaryotes, with perturbation of ubiquitin-mediated systems associated with the pathogenesis of many human diseases, including cancer and neurodegenerative disorders.
Item Type: | Article |
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Uncontrolled Keywords: | Apicomplexa, Plasmodium, Protein domains, Toxoplasma gondii, Ligases, Ubiquitin ligases, Cell cycle and cell division, Conjugated proteins |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | Faculty of Natural Sciences > School of Life Sciences |
Related URLs: | |
Depositing User: | Symplectic |
Date Deposited: | 26 Nov 2014 13:16 |
Last Modified: | 23 Aug 2018 13:57 |
URI: | https://eprints.keele.ac.uk/id/eprint/99 |