Helen McCarthy h.s.mccarthy@keele.ac.uk
Cell Therapy for Cartilage Repair
McCarthy; Perry; Hulme; Mennan; Wright
Authors
Jade Perry j.k.l.perry1@keele.ac.uk
Charlotte Hulme c.hulme1@keele.ac.uk
Claire Mennan c.mennan@keele.ac.uk
Karina Wright k.t.wright@keele.ac.uk
Abstract
Regenerative medicine, using cells as therapeutic agents for the repair or regeneration of tissues and organs, offers great hope for the future of medicine. Cell therapy for treating defects in articular cartilage has been an exemplar of translating this technology to the clinic, but it is not without its challenges. These include applying regulations, which were designed for pharmaceutical agents, to living cells. In addition, using autologous cells as the therapeutic agent brings additional costs and logistical challenges compared with using allogeneic cells. The main cell types used in treating chondral or osteochondral defects in joints to date are chondrocytes and mesenchymal stromal cells derived from various sources such as bone marrow, adipose tissue or umbilical cord. This review discusses some of their biology and pre-clinical studies before describing the most pertinent clinical trials in this area.
Acceptance Date | Aug 9, 2021 |
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Publicly Available Date | Mar 28, 2024 |
Files
Accepted_Cell Therapy for Cartilage Repair.docx
(5.7 Mb)
Document
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
etls-2021-0015c.pdf
(8 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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