Keele Research Repository

Article

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA. Orthopaedic Proceedings, 105-B (S9). 76 - 76.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Peffers, MJ, Roberts, S, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. American Journal of Sports Medicine.

Hopkins, T, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Richardson, JB, Gallacher, P, Bailey, A and Kuiper, JH ORCID: https://orcid.org/0000-0002-7023-4078 (2023) Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. Orthopaedic Journal of Sports Medicine, 11 (2). 23259671231151925 - ?.

Minshull, C, Gallacher, P, Roberts, S, Barnett, A, Kuiper, JH ORCID: https://orcid.org/0000-0002-7023-4078 and Bailey, A (2021) Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. European Journal of Applied Physiology, 121 (12). pp. 3551-3559.

Hopkins, T, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Kuiper, NJ ORCID: https://orcid.org/0000-0001-6173-1446, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Jermin, P, Gallacher, P and Kuiper, JH ORCID: https://orcid.org/0000-0002-7023-4078 (2021) An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, 10 (8).

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Peffers, MJ, Harrington, GMB, Wilson, E, Perry, J, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P and Wright Bevans, K ORCID: https://orcid.org/0000-0002-1377-9047 (2021) Identification of Candidate Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. American Journal of Sports Medicine, 49 (6). pp. 1512-1523.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Perry, J, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. The Bone and Joint Journal, 103-B (S2).

Garcia, J ORCID: https://orcid.org/0000-0002-7811-3078, Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Bastiaansen-Jenniskens, YM, Osch, GJVMV, Tins, B, Gallacher, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2020) The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes. Osteoarthritis and Cartilage Open, 2 (2). pp. 1-8.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P, Richardson, J and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2019) Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation. Journal of Cartilage and Joint Preservation.

Hulme, C, Wilson, EL, Fuller, HR ORCID: https://orcid.org/0000-0001-8868-896X, Roberts, S, Richardson, JB, Gallacher, P, Peffers, MJ, Shirran, SL, Botting, CH and Wright, KT (2018) Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Research and Therapy, 20.

Hulme, C, Wilson, E, Fuller, H ORCID: https://orcid.org/0000-0001-8868-896X, Roberts, S, Richardson, J, Gallacher, P, Peffers, MJ, Shirran, S, Botting, C and Wright, K (2018) Acute phase response signalling is altered following cartilage harvest in non-responders to Autologous Chondrocyte Implantation. Osteoarthritis and Cartilage, 26 (1). S167.

Hulme, C, Richardson, JB, Gallacher, P, Roberts, S and Wright, K (2018) Assessment of candidate predictive protein biomarkers for microfracture and osteotomy. Osteoarthritis and Cartilage, 26 (1). S191-S192.

Richardson, JB, Wright, KT, Wales, J, Kuiper, JH, McCarthy, HS, Gallacher, P, Harrison, PE and Roberts, S (2017) Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12 (5). pp. 493-501.

Hulme, C, Wilson, E, Peffers, M, Roberts, S, Simpson, D, Richardson, J, Gallacher, P and Wright, K (2017) Autologous chondrocyte implantation- derived synovial fluids display distinct responder and non-responder proteomic profiles. Arthritis Research and Therapy, 19 (1).

Hulme, C, Wilson, E, Peffers, M, Fuller, H ORCID: https://orcid.org/0000-0001-8868-896X, Roberts, S, Simpson, D, Richardson, J, Gallacher, P and Wright, K (2017) Poor clinical response to Autologous Chondrocyte Implantation is associated with a unique synovial fluid proteome profile. Osteoarthritis and Cartilage, 25 (1). S92.

Wright, KT, Kuiper, JH, Richardson, JB, Gallacher, P and Roberts, S (2017) The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. American Journal of Sports Medicine, 45 (8). pp. 1806-1814.

McCarthy, HS, Wright, KT, Williams, JM, Gallacher, P, Richardson, JB and Roberts, S (2016) Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation. International Journal of Experimental Pathology, 97 (6). A11 -A12.

Conference or Workshop Item

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Gallacher, P, Jermin, P, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) Altered Acute Phase Response (APR) signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation. In: British Orthopaedic Research Society (BORS) 2021, 13-14 September 2021, Virtual (Hosted by Imperial College London). (In Press)