Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1

Dormeyer, Matthias; Adams, Yvonne; Kramer, Bernd; Chakravorty, Srabasti; Tse, Man Tsuey; Pegoraro, Stefano; Whittaker, Lisa; Lanzer, Michael; Craig, Alister

doi:10.1128/aac.50.2.724-730.2006

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Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines (2002)
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Background. Chemokines produced by resident renal cells promote the infiltration of leukocyte subsets. We have analysed the chemotactic responses of CD3+ peripheral blood lymphocytes (PBLs) to factors secreted by proximal tubular epithelial cells (PT... Read More about Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines.

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Fractalkine (CX3CL1) is a transmembrane molecule with a CX3C chemokine domain attached to an extracellular mucin stalk which can induce both adhesion and migration of leucocytes. Mononuclear cell infiltration at renal tubular sites and associated tub... Read More about Fractalkine expression on human renal tubular epithelial cells: potential role in mononuclear cell adhesion.

The role of ICAM-1 in Plasmodium falciparum cytoadherence (2004)
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Parasite sequestration at microvascular sites is a fundamental phenomenon in the manifestation of the symptoms of malaria and the progression to severe disease. Here, we review the endothelial cell-expressed intercellular adhesion molecule-1 (ICAM-1)... Read More about The role of ICAM-1 in Plasmodium falciparum cytoadherence.

PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes (2005)
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The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a key virulence factor for this species of human malarial parasite. PfEMP1 is expressed on the surface of infected erythrocytes (IEs) and directly mediates adhesion to a variety of... Read More about PfEMP1 expression is reduced on the surface of knoblessPlasmodium falciparuminfected erythrocytes.

Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1 (2006)
Journal Article

Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors availa... Read More about Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1.