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Davies, R, Allen, S, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, Platt, M, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 and Kehoe, O ORCID: https://orcid.org/0000-0002-8702-275X (2023) Extracellular Vesicle Depletion Protocols of Foetal Bovine Serum Influence Umbilical Cord Mesenchymal Stromal Cell Phenotype, Immunomodulation, and Particle Release. International Journal of Molecular Sciences, 24 (11). 9242 - 9242.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, McCarthy, HS ORCID: https://orcid.org/0000-0001-9534-7565, Davies, R, Lan, T, Rix, L, Perry, J ORCID: https://orcid.org/0000-0002-5953-1389 and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) A comprehensive review of quantum bioreactor cell manufacture: Research and clinical applications. Cytotherapy.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) PROTEOMIC IDENTIFICATION OF PREDICTIVE AUTOLOGOUS CHONDROCYTE IMPLANTATION BIOMARKERS IN PLASMA. Orthopaedic Proceedings, 105-B (S9). 76 - 76.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Peffers, MJ, Roberts, S, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) Proteomic Analyses of Autologous Chondrocyte Implantation Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical Screening. American Journal of Sports Medicine.

Perry, J ORCID: https://orcid.org/0000-0002-5953-1389, Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Rix, L, McCarthy, HS ORCID: https://orcid.org/0000-0001-9534-7565, Lan, T, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Snow, M ORCID: https://orcid.org/0000-0002-1366-109X and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) Assessing Allogeneic Chondroprogenitor Manufacture Under Good Manufacturing Practice (GMP) Serum Free And Xeno-Free Conditions. Osteoarthritis and Cartilage, 31 (S1). S231-S232.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Williams, A, Vincent, T, Watt, FE and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) Commonality Between The Proteome Signatures Of Clinical Response To Surgically Sustained And Acute Traumatic Cartilage Injuries In Two Human Knee Cohorts. Osteoarthritis and Cartilage, 31 (S1). S357.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Garcia, J ORCID: https://orcid.org/0000-0002-7811-3078, Perry, J ORCID: https://orcid.org/0000-0002-5953-1389, Baird, D, Freeman, R, Kiely, N and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2023) Up-scale Manufacture of Chondrocytes from Adult and Juvenile Cartilage Donors for Allogeneic Chondrocyte Therapies. Osteoarthritis and Cartilage, 31 (S1).

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Fuller, HR ORCID: https://orcid.org/0000-0001-8868-896X, Riddell, J, Shirran, SL, Botting, CH, Osman, A and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) INVESTIGATION OF THE BLOOD PROTEOME IN RESPONSE TO SPINAL CORD INJURY IN RODENT MODELS. Spinal Cord.

Perry, J ORCID: https://orcid.org/0000-0002-5953-1389, Roelofs, AJ, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, McCarthy, HS ORCID: https://orcid.org/0000-0001-9534-7565, Richmond, A, Clark, SM, Riemen, AHK, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, De Bari, C and Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X (2021) Human Mesenchymal Stromal Cells Enhance Cartilage Healing in a Murine Joint Surface Injury Model. Cells, 10 (8). pp. 1-16.

Hopkins, T, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Kuiper, NJ ORCID: https://orcid.org/0000-0001-6173-1446, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Jermin, P, Gallacher, P and Kuiper, JH ORCID: https://orcid.org/0000-0002-7023-4078 (2021) An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. Cells, 10 (8).

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Lan, T, McCarthy, HS ORCID: https://orcid.org/0000-0001-9534-7565, Makwana, N and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) The Management of Talar Osteochondral Lesions - Current Concepts. The Journal of Arthoscopy and Joint Surgery, 8 (3). pp. 231-237.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Perry, J, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) Synovial Fluid Biomarkers for the Prediction of Patient Outcome following Microfracture or Osteotomy. The Bone and Joint Journal, 103-B (S2).

Bahsoun, S, Kuiper, J-H, Hulme, CH, Twigg, AJA, El Masri, W, Glass, C, Soni, B, Kumar, N, Chowdhury, JR, Osman, A and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) Evaluating patient perspectives on participating in scientific research and clinical trials for the treatment of spinal cord injury. Scientific Reports, 11 (1). 4361 - ?.

Wang, J, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Kuiper, JH ORCID: https://orcid.org/0000-0002-7023-4078, Zhang, W, Garcia, J, Cui, Z and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2020) Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues. Scientific Reports, 10 (1). 21658 - ?.

Bernardo Harrington, GM, Cool, P ORCID: https://orcid.org/0000-0002-4985-3085, Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Osman, A, Chowdhury, J, Kumar, N, Budithi, S and Wright, KT (2020) Routinely measured haematological markers can help to predict AIS scores following spinal cord injury. Journal of Neurotrauma.

Garcia, J ORCID: https://orcid.org/0000-0002-7811-3078, Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Bastiaansen-Jenniskens, YM, Osch, GJVMV, Tins, B, Gallacher, P and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2020) The synovial fluid from patients with focal cartilage defects contains mesenchymal stem/stromal cells and macrophages with pro- and anti-inflammatory phenotypes. Osteoarthritis and Cartilage Open, 2 (2). pp. 1-8.

Mennan, C, Garcia, J, McCarthy, H, Owen, S, Perry, J, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Banerjee, R, Richardson, JB and Roberts, S (2019) Human Articular Chondrocytes Retain Their Phenotype in Sustained Hypoxia While Normoxia Promotes Their Immunomodulatory Potential. Cartilage, 10 (4). pp. 467-479.

Brown, SJ, Harrington, GMB, Hulme, CH, Morris, R, Bennett, A, Tsang, W-H, Osman, A, Chowdhury, J, Kumar, N and Wright, KT (2019) A Preliminary Cohort Study Assessing Routine Blood Analyte Levels and Neurological Outcome after Spinal Cord Injury. Journal of Neurotrauma.

Wang, J, Wright, KT, Perry, J, Tins, B, Hopkins, T, Hulme, C, McCarthy, HS, Brown, A and Richardson, JB (2019) Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. Cell Transplantation, 28 (7). 924 - 931.

Mennan, C, Garcia, J, Roberts, S, Hulme, C and Wright, KT (2019) A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells. Stem Cell Research and Therapy, 10 (1).

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Gallacher, P, Jermin, P, Richardson, J and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2019) Matrix mettaloproteinase-3 (MMP-3) and tissue inhibitors of metalloproteinases-1 (TIMP-1): potential biomarkers to predict the outcome of Autologous Chondrocyte Implantation. Journal of Cartilage and Joint Preservation.

Hulme, C, Wilson, EL, Fuller, HR ORCID: https://orcid.org/0000-0001-8868-896X, Roberts, S, Richardson, JB, Gallacher, P, Peffers, MJ, Shirran, SL, Botting, CH and Wright, KT (2018) Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation. Arthritis Research and Therapy, 20.

Sykes, JG, Kuiper, JH, Richardson, JB, Roberts, S, Wright, KT and Kuiper, NJ (2018) Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. European Cells and Materials, 35. 255 - 267.

Mennan, C, Wright, KT, Garcia, J, Hulme, C and Roberts, S (2018) Assessing The Characteristics Of Human Mesenchymal Stromal Cells Derived From Bone Marrow And Umbilical Cord Following Expansion In The Quantum® Hollow-fibre Bioreactor System. Osteoarthritis and Cartilage, 26 (1). S146-S147.

Sykes, JG, Kuiper, J, Richardson, JB, Wright, KT and Kuiper, NJ (2018) Impact of human platelet lysate on the expansion and chondrogenic capacity of cultured human chondrocytes for cartilage cell therapy. Osteoarthritis and Cartilage, 26 (S1).

Richardson, JB, Wright, KT, Wales, J, Kuiper, JH, McCarthy, HS, Gallacher, P, Harrison, PE and Roberts, S (2017) Efficacy and safety of autologous cell therapies for knee cartilage defects (autologous stem cells, chondrocytes or the two): randomized controlled trial design. Regenerative Medicine, 12 (5). pp. 493-501.

Wright, KT, McCarthy, H, Forsyth, NR ORCID: https://orcid.org/0000-0001-5156-4824 and Roberts, S (2017) 283 - Characteristics of human bone marrow mscs are sensitive to mononuclear cell separation technique and oxygen tension. Cytotherapy, 19 (5). S197 - S197.

Wright, KT, Kuiper, JH, Richardson, JB, Gallacher, P and Roberts, S (2017) The absence of detectable ADAMTS-4 (aggrecanase-1) activity in synovial fluid is a predictive indicator of autologous chondrocyte implantation success. American Journal of Sports Medicine, 45 (8). pp. 1806-1814.

Hulme, CH, Brown, SJ, Fuller, HR ORCID: https://orcid.org/0000-0001-8868-896X, Riddell, J, Osman, A, Chowdhury, J, Kumar, N, Johnson, WE and Wright, KT (2016) The Developing Landscape of Diagnostic and Prognostic Biomarkers for Spinal Cord Injury in Cerebrospinal Fluid and Blood. Spinal Cord, 55 (2). pp. 114-125.

McCarthy, HS, Wright, KT, Williams, JM, Gallacher, P, Richardson, JB and Roberts, S (2016) Analysis of cartilage oligomeric matrix protein in synovial fluid, plasma and repair tissue of patients treated with autologous chondrocyte implantation. International Journal of Experimental Pathology, 97 (6). A11 -A12.

Garcia, J, Mennan, C, McCarthy, HS, Roberts, S, Richardson, JB and Wright, KT (2016) Chondrogenic Potency Analyses of Donor-Matched Chondrocytes and Mesenchymal Stem Cells Derived from Bone Marrow, Infrapatellar Fat Pad, and Subcutaneous Fat. Stem Cells Int, 2016. 6969726 - ?.

Turner, SA, Wright, KT, Jones, PN, Balain, B and Roberts, S (2016) Temporal Analyses of the Response of Intervertebral Disc Cells and Mesenchymal Stem Cells to Nutrient Deprivation. Stem Cells International, 2016. 5415901 - ?.

Kohli, N, Wright, KT, Sammons, RL, Jeys, L, Snow, M and Johnson, WEB (2015) An In Vitro Comparison of the Incorporation, Growth, and Chondrogenic Potential of Human Bone Marrow versus Adipose Tissue Mesenchymal Stem Cells in Clinically Relevant Cell Scaffolds Used for Cartilage Repair. Cartilage, 6 (4). 252 -263.

Walter, MNM, Kohli, N, Major, T, Fuller, H ORCID: https://orcid.org/0000-0001-8868-896X, Wright, KT, Kuiper, JH and Johnson, WEB (2015) Human mesenchymal stem cells stimulate EaHy926 endothelial cell migration: combined proteomic and in vitro analysis of the influence of donor-donor variability. Journal of Stem Cells and Regenerative Medicine, 11 (1). pp. 18-24.

Bara, JJ, Turner, S, Roberts, S, Griffiths, G, Benson, R, Trivedi, JM and Wright, KT (2015) High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro. Experimental Cell Research, 333 (1). 93 - 104.

Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Uchida, K, Bara, JJ, Roberts, S, El Masri, W and Johnson, WEB (2014) Spinal motor neurite outgrowth over glial scar inhibitors is enhanced by coculture with bone marrow stromal cells. Spine Journal, 14 (8). 1722 - 1733.

Wright, KT, Mennan, C, Fox, H, Richardson, JB, Banerjee, R and Roberts, S (2013) Characterization of the cells in repair tissue following autologous chondrocyte implantation in mankind: a novel report of two cases. Regenerative Medicine, 8 (6). 699 - 709.

Nakajima, H, Uchida, K, Guerrero, AR, Watanabe, S, Sugita, D, Takeura, N, Yoshida, A, Long, G, Wright, KT, Johnson, WEB and Baba, H (2012) Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury. Journal of Neurotrauma, 29 (8). 1614 - 1625.

Wright, KT, El Masri, W, Osman, A, Chowdhury, J and Johnson, WE (2011) Bone Marrow for the Treatment of Spinal Cord Injury: Mechanisms and Clinical Application. Stem Cells, 29 (2). pp. 169-178.

Wright, KT, El Masri, W, Osman, A, Chowdhury, J and Johnson, WEB (2011) Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells, 29 (2). 169 - 178.

Wright, KT, Seabright, R, Logan, A, Lilly, AJ, Khanim, F, Bunce, CM and Johnson, WEB (2010) Extracellular Nm23H1 stimulates neurite outgrowth from dorsal root ganglia neurons in vitro independently of nerve growth factor supplementation or its nucleoside diphosphate kinase activity. Biochemical and Biophysical Research Communications, 398 (1). 79 - 85.

Wright, KT, Griffiths, GJ and Johnson, WEB (2010) A comparison of high-content screening versus manual analysis to assay the effects of mesenchymal stem cell-conditioned medium on neurite outgrowth in vitro. Journal of Biomolecular Screening, 15 (5). 576 - 582.

Bajada, S, Marshall, MJ, Wright, KT, Richardson, JB and Johnson, WEB (2009) Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells. Bone, 45 (4). 726 - 735.

Wright, KT, Masri, WE, Osman, A, Roberts, S, Trivedi, J, Ashton, BA and Johnson, WEB (2008) The cell culture expansion of bone marrow stromal cells from humans with spinal cord injury: implications for future cell transplantation therapy. Spinal Cord, 46 (12). 811 - 817.

Wright, KT, El Masri, W, Osman, A, Roberts, S, Chamberlain, G, Ashton, BA and Johnson, WEB (2007) Bone marrow stromal cells stimulate neurite outgrowth over neural proteoglycans (CSPG), myelin associated glycoprotein and Nogo-A. Biochemical and Biophysical Research Communications, 354 (2). 559 - 566.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Perry, J ORCID: https://orcid.org/0000-0002-5953-1389, McCarthy, HS ORCID: https://orcid.org/0000-0001-9534-7565, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Snow, M, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X and Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X Cell Therapy for Cartilage Repair.

Conference or Workshop Item

McDonald, J, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, Peffers, MJ, Perry, J ORCID: https://orcid.org/0000-0002-5953-1389, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Newall, K, Henson, F and Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185 (2023) Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells. In: International Cartilage and Joint Preservation Society World Congress 2023, 09 - 12 September, Melia Hotel Sitges, Sitges/ Barcelona. (In Press)

Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908, Makwana, N, Bing, A, Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185 and McCarthy, HS ORCID: https://orcid.org/0000-0001-9534-7565 (2023) Total Nucleated Cell Count in Bone Marrow Aspirate Concentrate Does Not Predict the Proportion of Mesenchymal Stem Cells. In: International Joint and Cartilage Preservation Society World Congress 2023. (In Press)

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Garcia, J ORCID: https://orcid.org/0000-0002-7811-3078, Freeman, R, Kiely, N, Williams, D, Wright, J and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2022) Juvenile Chondrocytes: Novel Alternatives for Allogeneic Cell Therapy? In: International Cartilage Regeneration and Joint Preservation Society (ICRS) World Congress 2022. (In Press)

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Gallacher, P, Jermin, P, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2021) Altered Acute Phase Response (APR) signalling following cartilage harvest can be identified in the plasma of ‘non-Responder’ Patients to Autologous Chondrocyte Implantation. In: British Orthopaedic Research Society (BORS) 2021, 13-14 September 2021, Virtual (Hosted by Imperial College London). (In Press)

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Garcia, J, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Freeman, R, Kiely, N, Williams, D, Banerjee, R, Meyer, C and Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 (2020) The Up-Scale Manufacture of Chondrocytes for Allogeneic Cartilage Therapies. In: TERMIS-EU 2020 Chapter Meeting.

Hulme, CH ORCID: https://orcid.org/0000-0002-4961-2185, Roberts, S ORCID: https://orcid.org/0000-0003-1835-327X, Mennan, C ORCID: https://orcid.org/0000-0001-9532-753X, Wright, KT ORCID: https://orcid.org/0000-0001-8842-5908 and Snow, M (2020) IS ORTHOPAEDICS LEADING THE WAY IN GETTING CELL THERAPY TO THE CLINIC? In: Termis EU Chapter 2020.