Keele Research Repository

Article

Rotherham, M ORCID: https://orcid.org/0000-0002-9297-7681, Moradi, Y, Nahar, T, Mosses, D, Telling, ND ORCID: https://orcid.org/0000-0002-2683-5546 and El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 (2022) Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4. 981421 - ?.

Rotherham, M, Nahar, T, Broomhall, TJ, Telling, ND ORCID: https://orcid.org/0000-0002-2683-5546 and El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 (2022) Remote magnetic actuation of cell signalling for tissue engineering. Current Opinion in Biomedical Engineering, 24 (100410).

Dhillon, K, Aizel, K, Broomhall, TJ, Secret, E, Goodman, T, Rotherham, M, Telling, ND ORCID: https://orcid.org/0000-0002-2683-5546, Siaugue, JM, Ménager, C, Fresnais, J, Coppey, M, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 and Gates, MA ORCID: https://orcid.org/0000-0002-2901-1083 (2022) Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. Journal of the Royal Society Interface, 19 (196). 20220576 - ?.

Monaco, G, Qawasmi, F, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Forsyth, NR ORCID: https://orcid.org/0000-0001-5156-4824 and Stoddart, MJ (2022) Chondrogenic differentiation of human bone marrow MSCs in osteochondral implants under kinematic mechanical load is dependent on the underlying osteo component. Frontiers in Bioengineering and Biotechnology, 10. 998774 - ?.

Hu, B, Rotherham, M ORCID: https://orcid.org/0000-0002-9297-7681, Farrow, N, Roach, P ORCID: https://orcid.org/0000-0003-4135-9733, Dobson, J and El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 (2022) Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics. International Journal of Molecular Sciences, 23 (17).

Luo, L, Foster, NC, Man, KL, Brunet, M, Hoey, DA, Cox, SC, Kimber, SJ and El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 (2021) Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells. Biotechnology Journal.

Monaco, G, Ladner, YD, El Haj, AJ, Forsyth, NR, Alini, M and Stoddart, MJ (2021) Mesenchymal Stromal Cell Differentiation for Generating Cartilage and Bone-Like Tissues In Vitro. Cells, 10 (8).

Foster, NC, Allen, P, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Grover, LM and Moakes, RJA (2021) Tailoring Therapeutic Responses via Engineering Microenvironments with a Novel Synthetic Fluid Gel. Advanced Healthcare Materials, 10 (16). 1 - 12.

Markides, H, Foster, NC, McLaren, JS, Hopkins, T ORCID: https://orcid.org/0000-0002-0300-8230, Black, C, Oreffo, ROC, Scammell, BE, Echevarria, I, White, LJ and El Haj, AJ (2021) Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, 10 (7).

Monaco, G, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Alini, M and Stoddart, MJ (2021) Ex Vivo Systems to Study Chondrogenic Differentiation and Cartilage Integration. Journal of Functional Morphology and Kinesiology, 6 (1). pp. 1-32.

Kaggie, JD, Markides, H, Graves, MJ, MacKay, J, Houston, G, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Gilbert, F and Henson, F (2020) Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model. Scientific Reports, 10 (1). 8451 - ?.

Monaco, G, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Alini, M and Stoddart, MJ (2020) Sodium Hyaluronate Supplemented Culture Media as a New hMSC Chondrogenic Differentiation Media-Model for in vitro/ex vivo Screening of Potential Cartilage Repair Therapies. Frontiers in Bioengineering and Biotechnology, 8. 243 -?.

Dimmock, RL, Wang, X, Fu, Y ORCID: https://orcid.org/0000-0002-9617-0420, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 and Yang, Y (2020) Biomedical Applications of Wrinkling Polymers. Recent Progress in Materials, 2 (1). 1 - 31.

Helling, AL, Viswanathan, P, Cheliotis, KS, Mobasseri, SA, Yang, Y ORCID: https://orcid.org/0000-0002-1362-6040, El Haj, AJ and Watt, FM (2019) Dynamic Culture Substrates That Mimic the Topography of the Epidermal-Dermal Junction. Tissue Engineering Part A, 25 (3-4). 214 - 223.

Gater, R, Ipek, T, Sadiq, S, Nguyen, D, Jones, L, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 and Yang, Y ORCID: https://orcid.org/0000-0002-1362-6040 (2019) Investigation of Conjunctival Fibrosis Response Using a 3D Glaucoma Tenon’s Capsule + Conjunctival ModelFibrosis Response Within a 3D Tenon’s + Conjunctival Model. Investigative Ophthalmology & Visual Science, 60 (2). 605 -614.

Markides, H, Newell, KJ, Rudorf, H, Ferreras, LB, Dixon, JE, Morris, RH, Graves, M, Kaggie, J, Henson, F and El Haj, AJ (2019) Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model. STEM CELL RESEARCH & THERAPY, 10.

Moise, S, Byrne, JM, El Haj, AJ and Telling, ND (2018) The potential of magnetic hyperthermia for triggering the differentiation of cancer cells. Nanoscale, 10 (44). pp. 20519-20525.

Moser, C, Bardsley, K, El Haj, AJ, Alini, M, Stoddart, MJ and Bara, JJ (2018) A Perfusion Culture System for Assessing Bone Marrow Stromal Cell Differentiation on PLGA Scaffolds for Bone Repair. Frontiers in Bioengineering and Biotechnology, 6. 161 -161.

Henstock, JR, Rotherham, M and El Haj, AJ (2018) Magnetic ion channel activation of TREK1 in human mesenchymal stem cells using nanoparticles promotes osteogenesis in surrounding cells. Journal of Tissue Engineering, 9. 2041731418808695 - ?.

Harrison, R, Leija, HAL, Strohbuecker, S, Crutchley, J, Marsh, S, Denning, C, El Haj, AJ and Sottile, V (2018) Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing. Stem Cell Research & Therapy, 9.

Goncalves, A, Rotherham, M, Markides, H, Rodrigues, M, Reis, R, Gomes, M and El Haj, AJ (2018) Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation. Nanomedicine: Nanotechnology, Biology and Medicine, 14 (4). pp. 1149-1159.

Markides, H, McLaren, JS, Telling, ND, Alom, N, Al-Mutheffer, EA, Oreffo, ROC, Zannettino, A, Scammell, BE, White, LJ and El Haj, AJ (2018) Translation of remote control regenerative technologies for bone repair. NPJ Regenerative Medicine, 3.

Reinwald, Y and El Haj, AJ (2018) Hydrostatic pressure in combination with topographical cues affects the fate of bone marrow-derived human mesenchymal stem cells for bone tissue regeneration. Journal of Biomedical Materials Research A, 106 (3). 629 - 640.

Gillies, D, Gamal, W, Downes, A, Reinwald, Y, Yang, Y ORCID: https://orcid.org/0000-0002-1362-6040, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 and Bagnaninchi, PO (2018) Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy. Methods, 136. pp. 126-133.

Dale, T, Mazher, S, Webb, W, Zhou, J, Maffulli, N, Chen, GQ, El Haj, AJ and Forsyth, N (2018) Tenogenic differentiation of human embryonic stem cells. Tissue Engineering: Parts A, B, and C, 24 (5/6). pp. 361-368.

Rotherham, M, Henstock, J, Quatachi, O and El Haj, AJ (2018) Remote regulation of magnetic particle targeted Wnt signalling for bone tissue engineering. Nanomedicine: Nanotechnology, Biology and Medicine, 14 (1). pp. 173-184.

Chapman, V, Markides, H, Sagar, DR, Xu, L, Burston, JJ, Mapp, P, Kay, A, Morris, RH, Kehoe, O and El Haj, AJ (2017) Therapeutic Benefit for Late, but Not Early, Passage Mesenchymal Stem Cells on Pain Behaviour in an Animal Model of Osteoarthritis. Stem Cells International, 2017. 2905104 - ?.

Harrison, R, Markides, H, Morris, RH, Richards, P, El Haj, AJ and Sottile, V (2017) Autonomous magnetic labelling of functional mesenchymal stem cells for improved traceability and spacial control in cell therapy applications. Journal of Tissue Engineering and Regenerative Medicine, 11 (8). pp. 2333-2348.

Bardsley, K, Yang, Y and El Haj, AJ (2017) Fluorescent Labeling of Collagen Production by Cells for Noninvasive Imaging of Extracellular Matrix Deposition. Tissue Eng Part C Methods, 23 (4). 228 - 236.

Ismail, Y, Wimpenny, I, Bretcanu, O, Dalgarno, K and El Haj, AJ (2017) Development of multi-substituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications. Journal of Biomedical Materials Research Part A, 105 (6). pp. 1775-1785.

Moise, S, Céspedes, E, Soukup, D, Byrne, JM, El Haj, AJ and Telling, ND (2017) The cellular magnetic response and biocompatibility of biogenic zinc- and cobalt-doped magnetite nanoparticles. Scientific Reports, 7. 39922 - ?.

Lowndes, M, Rotherham, M, Price, J, El Haj, AJ and Habib, S (2016) Immobilized WNT Proteins Act as Stem Cell Niche for Tissue Engineering. Stem Cell Reports, 7 (1). 126 - 137.

Law, JX, Musa, F, Ruszymah, BH, El Haj, AJ and Yang, Y (2016) A comparative study of skin cell activities in collagen and fibrin constructs. Medical Engineering & Physics, 38 (9). 854 -861.

Bardsley, K, Wimpenny, I, Yang, Y ORCID: https://orcid.org/0000-0002-1362-6040 and El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678 (2016) Flourescent, online monitoring of PLGA degradation for regenerative medicine applications. RSC Advances, 6 (50). 44364 - 44370.

Price, J, Roach, P and El Haj, AJ (2016) Liquid crystalline ordered collagen substrates for applications in tissue engineering. ACS Biomaterials Science & Engineering, 2 (4). pp. 625-633.

El Haj, AJ, Nessler, KHL, Henstock, JR, Waters, SL and Whiteley, JP (2016) The influence of hydrostatic pressure on tissue engineered bone development. Journal of Theoretical Biology.

Dixon, JE, Osman, G, Morris, GE, Markides, H, Rotherham, M, Bayoussef, Z, El Haj, AJ, Denning, C and Shakesheff, KM (2016) Highly efficient delivery of functional cargoes by the synergistic effect of GAG binding motifs and cell-penetrating peptides. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113 (3). E291 - E299.

Gothard, D, Smith, EL, Kanczler, JM, Black, CR, Wells, JA, Roberts, CA, White, LJ, Qutachi, O, Peto, H, Rashidi, H, Rojo, L, Stevens, MM, El Haj, AJ, Rose, FR, Shakesheff, KM and Oreffo, RO (2015) In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors. PLoS One, 10 (12). e0145080 - ?.

Mazl Chanova, E, Knotek, P, Yang, Y ORCID: https://orcid.org/0000-0002-1362-6040, Machova, L, Proks, V, Kucka, J, Popelka, S, Pop-Georgievski, O, El Haj, AJ ORCID: https://orcid.org/0000-0003-3544-5678, Kubies, D and Rypacek, F (2015) Nano-colloid printing of functionalised PLA-b-PEO copolymers: Tailoring the surface pattern of adhesive motif and its effect on cell attachment. Physiological Research, 64 (1). 61 - 73.

Rotherham, M and El Haj, AJ (2015) Remote activation of the Wnt/β-catenin signalling pathway using functionalised magnetic particles. PLoS One, 10 (3). e0121761 - ?.

Kay, AG, Dale, TP, Akram, KM, Mohan, P, Hampson, K, Maffulli, N, Spiteri, MA, El Haj, AJ and Forsyth, NR (2015) BMP2 repression and optimized culture conditions promote human bone marrow-derived mesenchymal stem cell isolation. Regen Med, 10 (2). 109 - 125.

Chippendale, TW, Španěl, P, Smith, D and El Haj, AJ (2014) Counting cell number in situ by quantification of dimethyl sulphide in culture headspace. Analyst, 139 (19). 4903 - 4907.

Kehoe, O, Cartwright, A, Askari, A, El Haj, AJ and Middleton, J (2014) Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis. Journal of Translational Medicine, 12. 157 - ?.

Lisella, A and El Haj, AJ (2014) Determination of drug permeability in Caco-2 monolayers using mica technology. Journal of Tissue Engineering and Regenerative Medicine, 8. 222 - 223.

Rose, JB, Pacelli, S, El Haj, AJ, Dua, HS, Hopkinson, A, White, LJ and Rose, FRAJ (2014) Gelatin-Based Materials in Ocular Tissue Engineering. MATERIALS, 7 (4). 3106 - 3135.

Dong, CL, Webb, WR, Peng, Q, Tang, JZ, Forsyth, NR, Chen, GQ and El Haj, AJ (2014) Sustained PDGF-BB release from PHBHHx loaded nanoparticles in 3D hydrogel/stem cell model. Journal of Biomedical Materials Research Part A, 103 (1). 282 -288.

Markides, H, Kehoe, O, Morris, RH and El Haj, AJ (2013) Whole body tracking of superparamagnetic iron oxide nanoparticle-labelled cells--a rheumatoid arthritis mouse model. Stem Cell Research and Therapy, 4 (5). 126 -?.

Hu, B, El Haj, AJ and Dobson, J (2013) Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. International Journal of Molecular Sciences, 14 (9). 19276 - 19293.

Wilson, SL, El Haj, AJ and Yang, Y (2012) Control of scar tissue formation in the cornea: strategies in clinical and corneal tissue engineering. Journal of Functional Biomaterials, 3 (3). 642 -687.

Markides, H, Rotherham, M and El Haj, AJ (2012) Biocompatibility and Toxicity of Magnetic Nanoparticles in Regenerative Medicine. JOURNAL OF NANOMATERIALS, 2012.

Zhang, H, Kay, A, Forsyth, NR, Liu, K-K and El Haj, AJ (2012) Gene expression of single human mesenchymal stem cell in response to fluid shear. Journal of Tissue Engineering, 3 (1). pp. 1-8.

Wimpenny, I, Markides, H and El Haj, AJ (2012) Orthopaedic applications of nanoparticle-based stem cell therapies. Stem Cell Research and Therapy, 3 (2). 13 - ?.

Conference or Workshop Item

Billstrom, GH, Dawson, J, Hofmann, S, Muller, R, Stoddart, M, Alini, M, Redl, H, El Haj, AJ, Brown, R, Salih, V, Hilborn, J, Larsson, S and Oreffo, R (2016) Multicentre study reveals poor correlation between in vitro and in vivo assessments of biomaterials for bone-regeneration. In: UNSPECIFIED.

Wang, QG, Magnay, J, Nguyen, B, Thomas, CR, Zhang, Z, El Haj, AJ and Kuiper, NJ (2009) The relationship between mechanical forces and gene expression of single chondrocytes and chondrons. In: 55th Annual Meeting of the Orthopaedic Research Society, Mar 2009, Las Vegas.

Smith, Mark and El Haj, AJ In The Same Room - practical methods to encourage collaboration across scientific disciplines. In: Bridging the Gaps Network Event, 8 Sep 2011, University of the West of England.